store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 299 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 793 | 待询 |
产品描述 | Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde in a condensation reaction.Compound 48/80 trihydrochloride is a mast cell degranulator and histamine releaser. Compound 48/80 trihydrochloride inhibits phosphatidylinositol-specific phospholipase C activity in human platelets. |
体外活性 | Compound 48/80 trihydrochloride inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with similar efficiency (IC50s: 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction)). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80 [1]. |
体内活性 | Compound 48/80 trihydrochloride causes oxidative stress in the rat adrenal gland through mast cell degranulation. Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3, or 6 h) increases serum serotonin, histamine, and corticosterone levels at 0.5 h, but their increases were reduced thereafter [3]. |
别名 | C48/80 trihydrochloride |
分子量 | 629.1 |
分子式 | C32H48Cl3N3O3 |
CAS No. | 848035-21-2 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 12.58 mg/mL (20 mM), Sonication is recommended.
DMSO: 6.29 mg/mL (10 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 1.5896 mL | 7.9479 mL | 15.8957 mL | 39.7393 mL |
5 mM | 0.3179 mL | 1.5896 mL | 3.1791 mL | 7.9479 mL | |
10 mM | 0.159 mL | 0.7948 mL | 1.5896 mL | 3.9739 mL | |
H2O | 20 mM | 0.0795 mL | 0.3974 mL | 0.7948 mL | 1.987 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Compound 48/80 trihydrochloride 848035-21-2 Metabolism Phospholipase Compound 48/80 Compound 48/80 Trihydrochloride C48/80 Trihydrochloride C48/80 C48/80 trihydrochloride Inhibitor inhibitor inhibit